Beckman Instruments Biomek 2000 Manuale utente

Beckman Part No. 609909-AA

April 1998



Beckman Instruments, Inc.

2500 N. Harbor Blvd., Fullerton, CA 92834-3100

Biomek





2000

User’s Guide

reproduced, transcribed, transmitted, or translated into any language in any form by any means

without the written permission of Beckman Instruments, Inc.

The product warranty does not apply to software which is warranted on an “as is” basis without fitness

for any specific purpose with the exception of the media which is warranted against defects in materials

and workmanship for a period of one year.

The software is copyrighted and may not be altered or given to a third party without the written

authorization from Beckman Instruments.

User’s Guide

Document 609909-AA

Biomek 2000 i

Table of Contents

Notice

Safety Notice

Safety During Installation...........................................................................................vii

Electrical Safety..........................................................................................................vii

Safety Against Risk of Fire........................................................................................viii

Chemical and Biological Safety.................................................................................viii

Moving Parts..............................................................................................................viii

Cleaning.......................................................................................................................ix

Maintenance.................................................................................................................ix

Accessory Safety..........................................................................................................ix

Side Loader (SL)...........................................................................................................x

SL Incubator..................................................................................................................x

High-Density Replicating System................................................................................xi

Plate Reader.................................................................................................................xi

Wash System...............................................................................................................xii

Heater/Cooler Block ...................................................................................................xii

Biomek 2000 Safety Features............................................................................................xii

Summary of Warning Information ....................................................................................xii

Introduction

Introduction ......................................................................................................................1-1

Intended Use ..............................................................................................................1-1

Theory of Operation...................................................................................................1-1

Workstation Components...........................................................................................1-1

Automation Features..................................................................................................1-2

Modular Platform for Easy Upgrades........................................................................1-3

Pipette and Wash Tools.....................................................................................................1-3

Accessories ................................................................................................................1-5

BioWorks...................................................................................................................1-5

Interconnect Diagrams...............................................................................................1-5

Safety Features...........................................................................................................1-8

User’s Guide Table of Contents

Document 609909-AA

ii Biomek 2000

Safety Precautions

Safety During Installation......................................................................................... 2-1

Electrical Safety........................................................................................................ 2-1

Safety Against Risk of Fire....................................................................................... 2-1

Chemical and Biological Safety................................................................................ 2-2

Moving Parts............................................................................................................. 2-2

Cleaning .................................................................................................................... 2-3

Maintenance.............................................................................................................. 2-3

Accessory Safety....................................................................................................... 2-3

Side Loader (SL) ............................................................................................................. 2-4

SL Incubator ....................................................................................................................2-4

High-Density Replicating System ................................................................................... 2-5

Plate Reader..................................................................................................................... 2-5

Wash System.................................................................................................................... 2-6

Heater-Cooler Block........................................................................................................ 2-6

Biomek 2000 Safety Features ................................................................................... 2-6

Principles of Operation

General Information......................................................................................................... 3-1

The Edit Module ....................................................................................................... 3-1

Creating a Method..................................................................................................... 3-4

Setup, Initial Configuration, and Default Configuration................................................. 3-5

Setup.......................................................................................................................... 3-5

Initial Configuration.................................................................................................. 3-6

Default Configuration ............................................................................................... 3-7

Placing Labware on the Worksurface....................................................................... 3-8

Specifying a Method Step (Action) .......................................................................... 3-8

Error Messages During Labware Placement........................................................... 3-10

Pipette Transfers ..................................................................................................... 3-10

Source...................................................................................................................... 3-12

Destination .............................................................................................................. 3-14

Tool Options ........................................................................................................... 3-15

Tip Handling Options.............................................................................................. 3-15

Advanced Options................................................................................................... 3-16

Printing Methods ........................................................................................................... 3-18

Mix and Serial Transfer Pipetting Functions................................................................. 3-18

Mix.......................................................................................................................... 3-18

Serial Transfer......................................................................................................... 3-19

Tip Handling Functions................................................................................................. 3-20

Tip Change.............................................................................................................. 3-20

Reset Tip Rack ................................................................................................. 3-20

Wash Tool Functions .................................................................................................... 3-21

Wash........................................................................................................................ 3-21

Table of Contents User’s Guide

Document 609909-AA

Biomek 2000 iii

Aspirate....................................................................................................................3-21

Bulk Dispense..........................................................................................................3-22

Purge........................................................................................................................3-22

Labware Moves........................................................................................................3-23

Manual Moves .........................................................................................................3-23

Automatic Moves.....................................................................................................3-23

Editing Existing Methods..............................................................................................3-24

Saving Methods .......................................................................................................3-24

Running a Method..........................................................................................................3-25

Alarms and Suppress All Alarms.............................................................................3-25

Verify Configuration................................................................................................3-26

Save Preferences......................................................................................................3-26

Dry Run....................................................................................................................3-26

Stop and Quit Functions...........................................................................................3-26

Functional Verification and Self Diagnostics.................................................................3-26

Performance Characteristics and Specifications ............................................................3-27

Basic Operating Procedures

Basic Operating Procedures .............................................................................................4-1

Editing the BioWorks Demo Method........................................................................4-1

Changing the Initial Configuration............................................................................4-7

Viewing and Editing a Transfer Function..................................................................4-8

Adding a Transfer Function.....................................................................................4-11

Inserting Messages and Pauses................................................................................4-13

Saving a Method......................................................................................................4-16

Running a Method....................................................................................................4-17

Recommended Maintenance Procedures

Maintenance Procedures...................................................................................................5-1

General Information .........................................................................................................5-1

Weekly.......................................................................................................................5-1

Perform a Position Calibrate ...............................................................................5-1

Perform Check Disk............................................................................................5-1

Verify the Alignment Points................................................................................5-1

Check Finger Pads for Wear ...............................................................................5-2

Monthly...............................................................................................................5-2

Semi-Annually (Every Six Months) ..........................................................................5-2

Calibrate Pipetting Tools.....................................................................................5-2

Table of Contents User’s Guide

Document 609909-AA

Biomek 2000 iv

Parts, Supplies and Accessories

Diagnostics Overview ......................................................................................................6-1

General Information .........................................................................................................6-1

United States Sales Telephone Number.....................................................................6-1

World Wide Web.......................................................................................................6-1

Notice

Biomek 2000 v

Notice

This equipment has been tested and found to comply with the limits for a Class A

digital device, pursuant to part 15 of the FCC rules. These limits are designed to

provide reasonable protection against harmful interference with the equipment is

operated in a commercial environment. This equipment generates, uses, and can

radiate radio frequency energy and, if not installed and used in accordance with the

instruction manual, may cause harmful interference to radio communications.

Operation of this equipment in a residential area is likely to cause harmful interference

in which case the used will be required to correct the interference at his own expense.

This manual is copyrighted and all rights are reserved. This document may not, in

whole or in part, be copies, photocopied, reproduced, translated, or reduced to any

electronic medium or machine-readable form without prior consent, in writing, from

Beckman Instruments, Inc.

Biomek®and Beckman®are registered trademarks of Beckman Instruments, Inc.

BioWorks™ and BioScript™are trademarks of Beckman Instruments, Inc.

Microsoft®and MS-DOS®are registered trademarks and Windows™ is a trademark

of Microsoft Corporation.

Notice

vi Biomek 2000

Safety

Biomek 2000 vii

Safety Notice

The exclamation mark (contained in a triangle) is an international symbol displayed to

indicate to the user that all safety instructions should be read and understood before

installation and operation are attempted.

When you see the safety notice symbol on the instrument or on one of its accessories,

you should refer to this manual for specific safety information that applies. If the

product is used in a manner other than specified in the manual, the safety and

performance of the equipment could be impaired.

Any installation or service procedures not described in this manual must be performed

by qualified service personnel.

Safety During Installation

Do not lift the Biomek 2000 by the bridge. Two people are needed to lift the Biomek,

grasping the front rail and the back support.

Do not connect the Biomek to an electrical outlet until it is positioned properly on the

bench.

Electrical Safety

To reduce the risks of electrical shock, this equipment employs a three-wire electrical

cord and plug to connect the equipment to earth ground. To preserve this safety

feature:

• Make sure the matching wall outlet receptacle is properly wired and earth

grounded.

• Never use a three- to two-wire plug adapter

• Never use a two wire extension cord or a non-grounding type multiple outlet

receptacle strip

• Any servicing of this equipment which requires removal of any covers or panels

can expose parts which involve the risk of electric shock or personal injury. Refer

such servicing to Beckman-trained, qualified personnel

• Do not use any power supply other than the type supplied for the accessory for the

Biomek 2000, as appropriate for the country where it is installed.

•

Safety

viii Biomek 2000

Safety Against Risk of Fire

Certain electrical circuits within this equipment are protected by fuses against

over-current conditions. For continued protection against risk of fire, replace fuses

only with the same type and rating specified.

Chemical and Biological Safety

Normal operation of this equipment sometimes involves the use of reagents which are

toxic, flammable, or biologically harmful. When using such reagents, observe the

following precautions:

• Infectious samples must be handled according to good laboratory procedures and

methods to prevent the spread of disease

• Observe all cautionary information printed on the original solution containers prior

to their use

• All waste solutions must be disposed of according to your facility's waste disposal

procedures

• Liquid transfers may generate aerosols. Operate the Biomek in an

appropriate enclosure and take all necessary precautions when using

biohazardous, pathologic, toxic, or radioactive materials

• Objects dropped onto plates, accidental tool release, or other accidental collisions

may result in splashing of liquids; therefore take appropriate safety precautions,

such as the use of safety glasses when working with potentially hazardous liquids

• Use an appropriate containment environment when using hazardous materials

• Observe the appropriate cautionary procedures as defined by your safety officer

when using flammable solvents in or near a powered-up instrument

• Make sure that the vacuum is attached prior to any method that contains any wash

or aspirate functions

Moving Parts

The bridge and head assembly may suddenly move. To avoid injury due to moving

parts, you must observe the following:

• Never attempt to exchange labware, reagents, or tools while the instrument is

operating, as indicated by the amber safety light at the end of the bridge. When the

light is on, the workstation is in operation and may move suddenly and rapidly at

any moment. A beep sounds just prior to initial movement to provide additional

warning

• Never attempt to physically restrict the movement of the head and bridge

assembly. Use the Stop switch at the base of the workstation if an emergency stop

is required. Pressing this switch will freeze the workstation (but not the Side

Loader). Click on the Stop button on the Run window to stop the instrument if the

stop is not an emergency

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