Franklin IC-145 Manuale utente

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User’s Manual

HANDBOOK

ADVERSE

DRUG

INTERACTIONS

The Medical Letter



DIGITAL BOOK F

IC-145





Electronic Publishers

For Use with the Franklin

Digital Book System



Electronic Publishers

READ THIS LICENSE AGREEMENT BEFORE USING THE

DIGITAL BOOK. YOUR USE OF THE DIGITAL BOOK DEEMS

THAT YOU ACCEPT THE TERMS OF THIS LICENSE. IF YOU

DO NOT AGREE WITH THESE TERMS, YOU MAY RETURN

THIS PACKAGE WITH PURCHASE RECEIPT TO THE DEALER

FROM WHICH YOU PURCHASED THE DIGITAL BOOK AND

YOUR PURCHASE PRICE WILL BE REFUNDED. DIGITAL BOOK

means the software product and documentation found in this

package and FRANKLIN means Franklin Electronic Publishers, Inc.

LIMITED USE LICENSE

All rights in the DIGITAL BOOK remain the property of FRANKLIN.

Through your purchase, FRANKLIN grants you a personal and

nonexclusive license to use the DIGITAL BOOK on a single

FRANKLIN Digital Book System at a time. You may not make any

copies of the DIGITAL BOOK or of the data stored therein, whether

in electronic or print format. Such copying would be in violation of

applicable copyright laws. Further, you may not modify, adapt,

disassemble, decompile, translate, create derivative works of, or in

any way reverse engineer the DIGITAL BOOK. You may not export

or re-export, directly or indirectly, the DIGITAL BOOK without

compliance with appropriate governmental regulations. The

DIGITAL BOOK contains Franklin’s confidential and propriety

information which you agree to take adequate steps to protect from

unauthorized disclosure or use. This license is effective until

terminated. This license terminates immediately without notice from

FRANKLIN if you fail to comply with any provision of this license.

This digital book was developed for use by medical professionals.

No other use of this digital book can substitute for consultation with

yourphysician.

LicenseAgreement

Contents

Introduction .......................................................3

Overview of Operation......................................5

Installing the Digital Book ................................7

Viewing a Demonstration .................................9

Selecting Drugs................................................10

Correcting Misspellings ..................................12

Finding Brands, Generics, Groups ................14

Finding Interactions........................................ 16

Between Many Drugs ..................................16

For a Single Drug........................................ 18

Viewing References ........................................ 20

Sending Words to Other Books..................... 22

Digital Book System®.......................................23

Limited Warranty............................................. 25

Product Specifications ................................... 26

Key Guide .........................................................27

Index..................................................................30

This handbook offers a quick guide to possible adverse effects

of drug interactions, with brief recommendations for precaution-

ary measures. References are given to original reports that

provide more complete discussions of each interaction.

This book— lists adverse drug interactions, their mechanisms,

and recommendations for clinical management. These listings

are usually based on clinical reports in humans.

Reports of interactions between more than two drugs are

appearing in the medical literature with increasing frequency.

Where these have been documented, they are noted as

comments under interacting pairs of drugs. Interactions listed

for groups of drugs (such as “cephalosporins” or “antidepres-

sants, tricyclic”) may not have been reported for every drug in

the group; known exceptions to the interaction are noted.

It is not possible to determine the frequency of most interac-

tions. When an interaction is documented by one or two case

reports rather than by clinical studies or reports in many

patients, the year of each report is given as some indication of

frequency.

Omissions—Drugs for which we have no documented

interaction are not included. New adverse interactions are

continually being reported; the absence of an interaction does

not necessarily mean that drugs will not interact when given

concurrently. Interactions between general anesthetics and

drugs likely to be administered during surgery, such as

autonomic drugs and local anesthetics, are not included here.

Interactions useful in therapy, such as increased plasma

concentration of penicillin with concurrent use of probenecid,

are also not included.

Common additive effects, such as occur with the use of two

Introduction

antihypertensive agents or two central-nervous-system

depressants, are generally not included. Effects expected from

the mechanism of a drug’s action, such as that of potassium on

digitalis glycosides or calcium on calcium-entry blockers, and

useful antagonist effects, such as that between a poison and an

antidote, are not listed. Most interactions of drugs with foods,

beverages, or other nutrients are not included, but foods

interacting with monoamine oxidase inhibitors are included.

Mechanisms of Interaction—Genetic differences can affect

drug metabolism and interactions. Drugs can interact by

changing the metabolism of other drugs, either through

inhibition or induction of any of several hepatic enzyme

activities or through alterations in hepatic blood flow; by altering

the binding of other drugs to plasma proteins or tissue

receptors; by altering the distribution of drugs to active receptor

sites; by delaying or enhancing excretion; or by causing additive

or synergistic effects.

Recommendations—Monitoring is most important when one of

the interacting drugs is stopped or started. Some experienced

clinicians may prefer to monitor the patient’s clinical status

rather than follow serum concentration of drugs.

Important Notice: The Medical Letter Drug Interactions

Program reports interactions occurring in people, which

can be documented primarily by published reports.

These may not include interactions mentioned in other

sources, such as the manufacturer’s package insert,

which are extrapolated from animal studies or interac-

tions reported for related drugs.

Introduction

Overview of Operation

What the

Handbook

Can Do

The Medical Letter®Handbook ofAdverse Drug

Interactions

is a powerful reference. Using this

digital book, you can. . .

• find brand name drugs, generic drugs, drug

groups, and food groups,

• correct drug name misspellings,

• find foods that interact with MAO inhibitors,

• select up to 20 drugs and view a list of the

interactions between them,

• select a single drug and view a list of the drugs

with which it interacts,

• read descriptions and references about drug

interactions, and

• look up drugs and words in related digital books.

Read this User’s Manual to learn how.

ENTER

CLEAR

How the

Handbook

Works

The

Handbook

is easy to use. Here are the basics.

Highlight the HADI symbol and press .

At the main drug list, As you type, the drug

type a drug name. name is highlighted.

Then press .

Type another drug You see a message

name. Press . to “

SHOW INTERACTIONS.

”

Press . You see the interactions,

if any, between the drugs.

Press . You see a description of

the interaction.

Press . You’re ready to find

other interactions.

Overview of Operation

✓About Illustrations in this Manual

Some screen shots in this User’s Manual may

vary slightly from what you see on screen. These

variations do not mean that this digital book or

your Digital Book System is malfunctioning.

ENTER

Before you can use this digital book, you must install

it. Warning: If you install a digital book

while the

Digital Book System on, information that you entered

in other currently installed digital books may be erased.

1. Turn the Digital Book System off.

2. Install the digital book into a slot on the

back of the Digital Book System.

Align the tabs on the digital book with the notches

in the slot. Make sure its metal contacts face down.

3. Press .

4. Turn the wheel on the side of the Digital Book

System to adjust the screen contrast.

5. Press .

6. Press or to highlight the HADI symbol.

ON/OFF

CARD

Installing the Digital Book

7. Press .

This is the main drug list, where you select drugs

to find interactions.

Installing the Digital Book

ENTER

✓Resuming Where You Left Off

While using this digital book, you can turn off

the Digital Book System at any time. When you

turn the Digital Book System on again, the

screen that you last viewed appears. Any drugs

entered in your query list are saved, too.

✓Clearing the Main Drug List

You can always return to the main drug list by

pressing .

Note:

When you do, the

drugs in your query list are also cleared.

You can return to the previous screen without

clearing your query list by pressing .

CLEAR

BACK

Viewing a Demonstration

ENTER

CLEAR

Before you start using this digital book, you may

want to view a brief demonstration of what it can do.

1. Press at the main drug list.

2. Press to highlight “Demo.”

3. Press to start the demonstration.

4. Press to stop the demonstration.

✓ Help is Always at Hand

Except during the demonstration, you can view

a help message at any screen by pressing .

To read the help message, press . To exit it,

press .

HELP

BACK

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