Waters Autospec Premier Manuale

Autospec Premier

Operator’s Guide

71500089202/Revision B

DOCUMENT OR PARTS THEREOF MAY NOT BE REPRODUCED IN ANY

FORM WITHOUT THE WRITTEN PERMISSION OF THE PUBLISHER.

The information in this document is subject to change without notice and

should not be construed as a commitment by Waters Corporation. Waters

Corporation assumes no responsibility for any errors that may appear in this

document. This document is believed to be complete and accurate at the time

of publication. In no event shall Waters Corporation be liable for incidental or

consequential damages in connection with, or arising from, its use.

Trademarks

Waters is a registered trademarks of Waters Corporation, and MassLynx,

AutoSpec Premier and “THE SCIENCE OF WHAT’S POSSIBLE.” are

trademarks of Waters Corporation.

Other registered trademarks or trademarks are the sole property of their

owners.

iii

Customer comments

Waters’ Technical Communications department invites you to tell us of any

errors you encounter in this document or to suggest ideas for otherwise

improving it. Please help us better understand what you expect from our

documentation so that we can continuously improve its accuracy and

usability.

We seriously consider every customer comment we receive. You can reach us

at [email protected].

Contacting Waters

Contact Waters®with enhancement requests or technical questions regarding

the use, transportation, removal, or disposal of any Waters product. You can

reach us via the Internet, telephone, or conventional mail.

Safety considerations

Some reagents and samples used with Waters instruments and devices can

pose chemical, biological, and radiological hazards. You must know the

potentially hazardous effects of all substances you work with. Always follow

Good Laboratory Practice, and consult your organization’s safety

representative for guidance.

When you develop methods, follow the “Protocol for the Adoption of Analytical

Methods in the Clinical Chemistry Laboratory,” American Journal of Medical

Technology, 44, 1, pages 30–37 (1978). This protocol addresses good operating

procedures and the techniques necessary to validate system and method

performance.

Waters contact information

Contacting medium Information

Internet The Waters Web site includes contact

information for Waters locations worldwide.

Visit www.waters.com.

Telephone and fax From the USA or Canada, phone 800

252-HPLC, or fax 508 872 1990.

For other locations worldwide, phone and fax

numbers appear in the Waters Web site.

Conventional mail Waters Corporation

34 Maple Street

Milford, MA 01757

USA

Considerations specific to the Autospec Premier

The Waters®AutoSpec Premier™mass spectrometer is designed solely for use

as a mass spectrometer; any attempt to use it for any other purpose can

damage the instrument, and will invalidate its warranty.

The instrument conforms to European standard EN61010-1:2001, safety

requirements for electrical equipment for measurement, control, and

laboratory use – Part 1: General requirements.

The instrument was designed and tested according to recognized safety

standards. If the instrument is used in a manner not specified by the

manufacturer, the protection provided to the user can be impaired.

When the safety protection of the instrument is compromised, disconnect the

instrument from all power sources, and secure the instrument against

unintended operation.

The instrument must be installed so that the operator can easily isolate the

instrument from the main power supply at all times.

Solvent leakage hazard

The source exhaust system is designed to be robust and leak-tight. Waters

recommends you perform a hazard analysis, assuming a maximum leak into

the laboratory atmosphere of 10% LC eluate.

Warning:

• To confirm the integrity of the source exhaust system, renew

the source O-rings at intervals not exceeding one year.

• To avoid chemical degradation of the source O-rings, which can

withstand exposure only to certain solvents see “Solvents used

to prepare mobile phases” on page B-3, to determine whether

any solvents you use that are not listed are chemically

compatible with the composition of the O-rings.

Flammable solvents hazard

Never let the nitrogen supply pressure fall below 400 kPa (4 bar, 58 psi)

during analyses that require flammable solvents. Connect to the LC output

with a gas-fail connector to stop the LC solvent if the nitrogen supply fails.

Warning: To prevent the ignition of accumulated solvent vapors inside

the source, maintain a continuous flow of nitrogen through the source

whenever significant amounts of flammable solvents are used during

instrument operation.

vii

Pinch hazard

Pinch hazard at front of instrument

Pinch hazard at rear of instrument

Warning: A pinch hazard exists at the front and rear of the instrument.

Do not put your fingers between the air mount frame and top of the

instrument’s cubicles (highlighted on the illustrations below).

Pinch

hazard

Pinch hazard

viii

High temperature hazard

Autospec Premier high temperature hazard

High voltage hazard

Warning: To avoid burn injuries, avoid touching the GC interface with

your unprotected hand when operating or servicing the instrument

(indicated in red on the figure below).

Warning:

• To avoid electric shock, do not remove the instrument’s protective

panels. The components they cover are not user-serviceable.

• To avoid nonlethal electric shock when the instrument is in Operate

mode, avoid touching the areas marked with the high voltage

warning symbol. To touch those areas, first put the instrument in

Standby mode.

GC interface

Hazards associated with removing an instrument from service

When you remove the instrument from use to repair or dispose of it, you must

decontaminate all of its vacuum areas. These are the areas in which you can

expect to encounter the highest levels of contamination:

• Source interior

• Waste tubing

• Exhaust system

• Rotary pump oil (where applicable)

The need to decontaminate other vacuum areas of the instrument depends on

the kinds of samples the instrument analyzed and their levels of

concentration. Do not dispose of the instrument or return it to Waters for

repair until the authority responsible for approving its removal from the

premises specifies the extent of decontamination required and the level of

residual contamination permissible. Management must also prescribe the

method of decontamination to be used and the appropriate protection for

personnel undertaking the decontamination process.

You must handle items such as syringes, fused silica lines, and borosilicate

tips used to carry sample into the source area in accordance with laboratory

procedures for contaminated vessels and sharps. To avoid contamination by

carcinogenic, toxic, or biohazardous substances, you must wear nitrile gloves

when handling or disposing of used oil.

Warning: To avoid personal contamination with

biohazardous or toxic materials, wear nitrile gloves during

all phases of instrument decontamination.

High magnetic field hazard

Safety advisories

Consult Appendix A for a comprehensive list of warning and caution

advisories.

Warning: Do not use the instrument if you have a cardiac pacemaker.

Electromagnetic interference and magnetic fields disrupt a

pacemaker’s operation.

Warning: The magnetic field generated by the instrument is not

quantified in terms of risk.

When working with the instrument:

• Do not use any ferrous tools.

• Remove any magnetic items from your person.

These can become ballistic items that are a physical threat if they

are allowed too close to the magnet.

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