Waters Xevo TQD Manuale operativo

Waters Xevo TQD

Overview and Maintenance Guide

715004387 / Revision B

ii March 14, 2014, 715004387 Rev. B

March 14, 2014, 715004387 Rev. B iii

General Inform ation

DOCUMENT OR PARTS THEREOF MAY NOT BE REPRODUCED IN ANY

FORM WITHOUT THE WRITTEN PERMISSION OF THE PUBLISHER.

The information in this document is subject to change without notice and

should not be construed as a commitment by Waters Corporation. Waters

Corporation assumes no responsibility for any errors that may appear in this

document. This document is believed to be complete and accurate at the time

of publication. In no event shall Waters Corporation be liable for incidental or

consequential damages in connection with, or arising from, its use. For the

most recent revision of this document, consult the Waters Web site

(waters.com).

Trademarks

ACQUITY, ACQUITY UltraPerformance LC, ACQUITY UPLC, Alliance,

Connections INSIGHT, ESCi, MassLynx, nanoACQUITY, nanoACQUITY

UPLC, nanoTile, “THE SCIENCE OF WHAT’S POSSIBLE”, TRIZAIC,

UNIFI, UPLC, Waters, Waters Quality Parts, and Xevo are registered

trademarks of Waters Corporation, and IntelliStart, IonSABRE, NanoFlow,

RADAR, T-Wave, and ZSpray are trademarks of Waters Corporation.

DART is a registered trademark of JEOL USA Inc.

GELoader is a registered trademark of New Brunswick Scientific, Co., Inc.

LDTD is a trademark of Phytronix Technologies Inc.

PEEK is a trademark of Victrex Corporation.

Phillips and Pozidriv are registered trademarks of Phillips Screw Company,

Inc.

snoop and Swagelok are registered trademarks of Swagelok Company.

Spark Holland and Symbiosis are trademarks of Spark-Holland BV.

Viton is a registered trademark of DuPont.

Other registered trademarks or trademarks are the sole property of their

owners.

iv March 14, 2014, 715004387 Rev. B

Customer comments

Waters’ Technical Communications organization invites you to report any

errors that you encounter in this document or to suggest ideas for otherwise

improving it. Help us better understand what you expect from our

documentation so that we can continuously improve its accuracy and

usability.

We seriously consider every customer comment we receive. You can reach us

at [email protected].

Contacting Waters

Contact Waters®with enhancement requests or technical questions regarding

the use, transportation, removal, or disposal of any Waters product. You can

reach us via the Internet, telephone, or conventional mail.

Safety considerations

Some reagents and samples used with Waters instruments and devices can

pose chemical, biological, or radiological hazards (or any combination thereof).

You must know the potentially hazardous effects of all substances you work

Waters contact information:

Contacting medium Information

Internet The Waters Web site includes contact

information for Waters locations worldwide.

Visit www.waters.com.

Telephone and fax From the USA or Canada, phone

800 252-4752, or fax 508 872 1990.

For other locations worldwide, phone and fax

numbers appear in the Waters Web site.

Conventional mail Waters Corporation

34 Maple Street

Milford, MA 01757

USA

March 14, 2014, 715004387 Rev. B v

with. Always follow Good Laboratory Practice, and consult your organization’s

standard operating procedures.

Safety hazard symbol notice

Documentation needs to be consulted in all cases where the symbol is

used to find out the nature of the potential hazard and any actions which have

to be taken.

Considerations specific to the Xevo TQD

Power cord replacement hazard

Solvent leakage hazard

The source exhaust system is designed to be robust and leak-tight. Waters

recommends you perform a hazard analysis, assuming a maximum leak into

the laboratory atmosphere of 10% LC eluate.

Warning: To avoid electric shock, use the SVT-type power cord in the

United States and HAR-type (or better) in Europe. The main power cord

must only be replaced with one of adequate rating. For information

regarding what cord to use in other countries, contact your local Waters

distributor.

Warning:

• To confirm the integrity of the source exhaust system, renew

the source O-rings at intervals not exceeding one year.

• To avoid chemical degradation of the source O-rings, which can

withstand exposure only to certain solvents (see page 244),

determine whether any solvents you use that are not listed are

chemically compatible with the composition of the O-rings.

vi March 14, 2014, 715004387 Rev. B

Spilled solvents hazard

Flammable solvents hazard

When using flammable solvents, ensure that a stream of nitrogen

continuously flushes the instrument’s source, and the nitrogen supply

pressure remains above 400 kPa (4 bar, 58 psi). You must also install a

gas-fail device that interrupts the solvent flowing from the LC system in the

event the supply of nitrogen fails.

Overload hazard

Prohibited: To avoid injury or equipment damage caused by spilled

solvent, do not place reservoir bottles on top of the instrument or on its

front ledge, unless in the bottle tray provided.

Warning: To prevent ignition of flammable solvent vapors in the

enclosed space of a mass spectrometer’s ion source, ensure that nitrogen

flows continuously through the source. The nitrogen supply pressure

must not fall below 400 kPa (4 bar, 58 psi) during an analysis requiring

the use of flammable solvents. Also a gas-fail device must be installed, to

interrupt the flow of LC solvent should the nitrogen supply fail.

Warning: To prevent personal injury, ensure equipment placed on top of

the Xevo®TQD does not exceed 15kg.

March 14, 2014, 715004387 Rev. B vii

Glass-breakage hazard

High temperature hazard

Xevo TQD high temperature hazard:

Warning: To avoid injuries from broken glass, falling objects,

or exposure to toxic or biohazardous substances, never place

containers on top of the instrument or on its front covers.

Warning: To avoid burn injuries, ensure the source heater is turned off

and the ion block is cool before performing maintenance on these

components. The source ion block, located behind the source enclosure

assembly, can become hot.

TP03406

Source enclosure assembly

viii March 14, 2014, 715004387 Rev. B

Hazards associated with removing an instrument from service

When you remove the instrument from use to repair or dispose of it, you must

decontaminate all of its vacuum areas. These are the areas in which you can

expect to encounter the highest levels of contamination:

• Source interior

• Waste tubing

• Exhaust system

• Rotary pump oil (where applicable)

The need to decontaminate other vacuum areas of the instrument depends on

the kinds of samples the instrument analyzed and their levels of

concentration. Do not dispose of the instrument or return it to Waters for

repair until the authority responsible for approving its removal from the

premises specifies the extent of decontamination required and the level of

residual contamination permissible. That authority must also prescribe the

method of decontamination to be used and the appropriate protection for

personnel undertaking the decontamination process.

You must handle items such as syringes, fused silica lines, and borosilicate

tips used to carry sample into the source area in accordance with laboratory

procedures for contaminated vessels and sharps. To avoid contamination by

carcinogens, toxic substances, or biohazards, you must wear

chemical-resistant gloves when handling or disposing of used oil.

Bottle placement prohibition

Warning: To avoid personal contamination with biohazards,

toxic materials, or corrosive materials, wear

chemical-resistant gloves during all phases of instrument

decontamination.

Warning: To avoid puncture injuries, handle syringes, fused

silica lines, and borosilicate tips with extreme care.

Prohibited: To avoid injury from electric shock or fire, and to prevent

damage to the workstation and ancillary equipment, do not place objects

filled with liquid—such as solvent bottles—on these items, or expose

them to dripping or splashing liquids.

March 14, 2014, 715004387 Rev. B ix

FCC radiation emissions notice

Changes or modifications not expressly approved by the party responsible for

compliance, could void the users authority to operate the equipment. This

device complies with Part 15 of the FCC Rules. Operation is subject to the

following two conditions: (1) this device may not cause harmful interference,

and (2) this device must accept any interference received, including

interference that may cause undesired operation.

Electrical power safety notice

Do not position the instrument so that it is difficult to operate the

disconnecting device.

Equipment misuse notice

If the equipment is used in a manner not specified by the manufacturer, the

protection provided by the equipment may be impaired.

Safety advisories

Consult Appendix A for a comprehensive list of warning advisories and

notices.

x March 14, 2014, 715004387 Rev. B

Operating this instrument

When operating this instrument, follow standard quality-control (QC)

procedures and the guidelines presented in this section.

Applicable symbols

Symbol Definition

Manufacturer

Date of manufacture

Part number catalog number

Serial number

Supply ratings

Authorized representative of the European

Community

Confirms that a manufactured product complies

with all applicable European Community

directives

Australia EMC Compliant

Confirms that a manufactured product complies

with all applicable United States and Canadian

safety requirements

5()

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