Waters ACQUITY Manuale operativo
ACQUITY QDa Detector
Overview and Maintenance Guide
715003956
Revision F
Copyright © Waters Corporation 2017
All rights reserved
General information
Copyright notice
© 2013 – 2017 WATERS CORPORATION. PRINTED IN THE UNITED STATES OF AMERICA
AND IN IRELAND. ALL RIGHTS RESERVED. THIS DOCUMENT OR PARTS THEREOF MAY
NOT BE REPRODUCED IN ANY FORM WITHOUT THE WRITTEN PERMISSION OF THE
PUBLISHER.
The information in this document is subject to change without notice and should not be construed
as a commitment by Waters Corporation. Waters Corporation assumes no responsibility for any
errors that may appear in this document. This document is believed to be complete and accurate
at the time of publication. In no event shall Waters Corporation be liable for incidental or
consequential damages in connection with, or arising from, its use. For the most recent revision
of this document, consult the Waters website (waters.com).
Trademarks
ACQUITY® is a registered trademark of Waters Corporation.
Alliance® is a registered trademark of Waters Corporation.
Connections INSIGHT® is a registered trademark of Waters Corporation.
PEEKTM is a trademark of Victrex PLC.
POZIDRIV® is a registered trademark of Phillips Screw Company.
QDa® is a registered trademark of Waters Corporation.
RADARTM is a trademark of Waters Corporation.
THE SCIENCE OF WHAT'S POSSIBLE® is a registered trademark of Waters Corporation.
Tygon® is a registered trademark of Saint-Gobain Performance Plastics Corporation.
VACUUBRAND® is a registered trademark of VACUUBRAND GMBH + CO KG.
Viton® is a registered trademark of DuPont Performance Elastomers LLC.
Waters® is a registered trademark of Waters Corporation.
Waters Quality Parts® is a registered trademark of Waters Corporation.
All other trademarks are property of their respective owners.
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Customer comments
Waters’ Technical Communications organization invites you to report any errors that you
encounter in this document or to suggest ideas for otherwise improving it. Help us better
understand what you expect from our documentation so that we can continuously improve its
accuracy and usability.
We seriously consider every customer comment we receive. You can reach us at
Contacting Waters
Contact Waters with enhancement requests or technical questions regarding the use,
transportation, removal, or disposal of any Waters product. You can reach us via the Internet,
telephone, fax, or conventional mail.
Waters contact information
Contacting medium Information
Internet The Waters Web site includes contact information for Waters locations
worldwide.
Visit www.waters.com
Telephone and fax From the USA or Canada, phone 800-252-4752, or fax 508-872-1990.
For other locations worldwide, phone and fax numbers appear in the
Waters Web site.
Conventional mail Waters Corporation
Global Support Services
34 Maple Street
Milford, MA 01757
USA
Safety considerations
Some reagents and samples used with Waters instruments and devices can pose chemical,
biological, or radiological hazards (or any combination thereof). You must know the potentially
hazardous effects of all substances you work with. Always follow Good Laboratory Practice
(GLP), and consult your organization’s standard operating procedures as well as your local
requirements for safety.
June 15, 2017, 715003956 Rev. F
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Safety hazard symbol notice
Documentation needs to be consulted in all cases where the symbol is used to find out the
nature of the potential hazard and any actions which have to be taken.
Considerations specific to the device
Power cord replacement hazard
Warning: To avoid electric shock, use SVT-type power cords in the United States and
HAR-type (or better) cords in Europe. The power cords must be replaced only with ones
of adequate rating. For information regarding which cord to use in other countries,
contact your local Waters distributor.
Solvent leakage hazard
The source exhaust system is designed to be robust and leak-tight. Waters recommends that you
perform a hazard analysis, assuming a maximum leak into the laboratory atmosphere of 10% LC
eluate. If the instrument is a standard QDa fitted with a diaphragm pump, assume an additional
0.5% maximum leak into the laboratory atmosphere.
Warning: To avoid exposure to toxic substances and biohazards from O-ring leaks in the
source exhaust system, observe these precautions:
• Replace the source O-rings at intervals not exceeding one year.
• Prevent chemical degradation of the source O-rings, which can withstand exposure only to
certain solvents, by determining whether any solvents you use are chemically compatible with
the composition of the O-rings.
Flammable solvents hazard
Warning: To prevent the ignition of flammable solvent vapors in the enclosed space of
a mass spectrometer’s ion source, ensure these conditions are met:
• Nitrogen flows continuously through the source.
• A gas-fail device is installed, to interrupt the flow of LC solvent should the nitrogen
supply fail.
• The nitrogen supply pressure does not fall below 600 kPa (6 bar, 87 psi) during an
analysis requiring the use of flammable solvents.
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High temperature hazard
Warning: To avoid burn injuries, exercise care when handling the components of the
source enclosure heated to high temperatures. Wait until the hot components have
sufficiently cooled before you handle them.
Mass spectrometer high temperature hazard
Source enclosure
Source components
High-voltage hazard
Warning: To avoid electric shock, observe these precautions:
• Do not remove the mass spectrometer’s protective panels. The components they
cover are not user-serviceable.
• When the instrument is in Operate mode, avoid touching the areas marked with the
high voltage warning symbol. To touch external areas marked with the symbol, first
put the instrument in Standby mode.
Hazards associated with removing an instrument from service
Warning: To avoid personal contamination with biologically hazardous, toxic, and corrosive
materials, wear chemical-resistant, powder-free gloves when performing this procedure.
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Warning: To avoid puncture injuries, handle sample needles, syringes, fused silica
lines, and borosilicate tips with extreme care.
Warning: To avoid eye injury from broken fused silica lines, use eye protection when
performing this procedure.
When you remove the instrument from use to repair or dispose of it, you must decontaminate all
of its vacuum areas. These are the areas in which you can expect to encounter the highest levels
of contamination:
• Source interior
• Waste tubing
• Exhaust system
• Rotary pump oil (where applicable)
The need to decontaminate other vacuum areas of the instrument depends on the kinds of
samples the instrument analyzed and their levels of concentration. Do not dispose of the
instrument or return it to Waters for repair until the authority responsible for approving its removal
from the premises specifies the extent of decontamination required and the level of residual
contamination permissible. That authority must also prescribe the method of decontamination to
be used and the appropriate protection for personnel undertaking the decontamination process.
You must handle items such as syringes, fused silica lines, and borosilicate tips used to carry
sample into the source area in accordance with laboratory procedures for contaminated vessels
and sharps. To avoid contamination by carcinogens, toxic substances, or biohazards, you must
wear chemical-resistant gloves when handling or disposing of used oil.
Bottle placement prohibition
Warning: To avoid injury from electrical shock or fire, and damage to the equipment, follow
these guidelines:
• Do not expose the workstation or ancillary equipment to dripping or splashing liquids.
• Do not place objects filled with liquid, such as solvent bottles, on top of the workstation or
ancillary equipment.
Electrical power safety notice
Do not position the instrument so that it is difficult to disconnect the power cord.
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Equipment misuse notice
If equipment is used in a manner not specified by its manufacturer, protections against personal
injury inherent in the equipment’s design can be rendered ineffective.
Safety advisories
Consult the "Safety advisories" appendix in this publication for a comprehensive list of warning
advisories and notices.
Operating this device
When operating this device, follow standard quality-control (QC) procedures and the guidelines
presented in this section.
Applicable symbols
The following symbols can be present on the device, system, or packaging.
Symbol Definition
Manufacturer
Date of manufacture
Authorized representative of the European Community
Confirms that a manufactured product complies with all applicable
European Community directives
or
Australia EMC compliant
Confirms that a manufactured product complies with all applicable United
States and Canadian safety requirements
Consult instructions for use
Alternating current
June 15, 2017, 715003956 Rev. F
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Symbol Definition
Electrical and electronic equipment with this symbol may contain
hazardous substances and should not be disposed of as general waste.
For compliance with the Waste Electrical and Electronic Equipment
Directive (WEEE) 2012/19/EU, contact Waters Corporation for the correct
disposal and recycling instructions.
Serial number
REF
Part number, catalog number
Audience and purpose
This guide is for novice users and assumes no knowledge of liquid chromatography or mass
spectrometry principles. It provides an overview of the instrument and explains how to install it,
prepare it for operation, and maintain it.
Intended use of the ACQUITY QDa detector
Waters designed the ACQUITY QDa detector for use as an ion confirmation and quantitation tool,
as part of an ACQUITY UPLC or UPC² system, Alliance, and LC and SFC prep systems. The
ACQUITY QDa detector is not intended for use in diagnostic applications.
Calibrating
To calibrate LC systems, adopt acceptable calibration methods using at least five standards to
generate a standard curve. The concentration range for standards must include the entire range
of QC samples, typical specimens, and atypical specimens.
Quality control
Routinely run three QC samples that represent subnormal, normal, and above-normal levels of a
compound. If sample trays are the same or very similar, vary the location of the QC samples in
the trays. Ensure that QC sample results fall within an acceptable range, and evaluate precision
from day to day and run to run. Data collected when QC samples are out of range might not be
valid. Do not report these data until you are certain that the instrument performs satisfactorily.
June 15, 2017, 715003956 Rev. F
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EMC considerations
FCC radiation emissions notice
Changes or modifications not expressly approved by the party responsible for compliance, could
void the user's authority to operate the equipment. This device complies with Part 15 of the FCC
Rules. Operation is subject to the following two conditions: (1) this device may not cause harmful
interference, and (2) this device must accept any interference received, including interference that
may cause undesired operation.
Canada spectrum management emissions notice
This class A digital product apparatus complies with Canadian ICES-001.
Cet appareil numérique de la classe A est conforme à la norme NMB-001.
ISM classification: ISM group 1 class A
This classification has been assigned in accordance with CISPR 11 Industrial Scientific and
Medical (ISM) instruments requirements.
Group 1 products apply to intentionally generated and/or used conductively coupled radio-
frequency energy that is necessary for the internal functioning of the equipment.
Class A products are suitable for use in all establishments other than residential locations and
those directly connected to a low voltage power supply network supplying a building for domestic
purposes.
There may be potential difficulties in ensuring electromagnetic compatibility in other environments
due to conducted as well as radiated disturbances.
EMC emissions
Do not use the equipment in close proximity to sources of strong electromagnetic radiation (for
example, unshielded intentional RF sources). The radiation can interfere with the equipment’s
proper operation.
This equipment complies with the emission and immunity requirements described in the relevant
parts of IEC/EN 61326: Electrical equipment for measurement, control, and laboratory use —
EMC requirements.
June 15, 2017, 715003956 Rev. F
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EC authorized representative
Address Waters Corporation
Stamford Avenue
Altrincham Road
Wilmslow SK9 4AX UK
Telephone +44-161-946-2400
Fax +44-161-946-2480
Contact Quality manager
June 15, 2017, 715003956 Rev. F
Page x
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