Waters Xevo TQ-S cronos Manuale operativo
Waters Xevo TQ-S cronos
Overview and Maintenance Guide
715006200
Version 01 (previously released as Rev. A)
Copyright © Waters Corporation 2022
All rights reserved
General information
Audience and purpose
This guide is for operators of varying levels of experience. It gives an overview of the device and
explains how to prepare it for operation, change its modes of operation, and maintain it.
Copyright notice
© 2019 – 2022 WATERS CORPORATION. PRINTED IN THE UNITED STATES OF AMERICA
AND IN IRELAND. ALL RIGHTS RESERVED. THIS DOCUMENT OR PARTS THEREOF MAY
NOT BE REPRODUCED IN ANY FORM WITHOUT THE WRITTEN PERMISSION OF THE
PUBLISHER.
The information in this document is subject to change without notice and should not be construed
as a commitment by Waters Corporation. Waters Corporation assumes no responsibility for any
errors that may appear in this document. This document is believed to be complete and accurate
at the time of publication. In no event shall Waters Corporation be liable for incidental or
consequential damages in connection with, or arising from, its use. For the most recent revision
of this document, consult the Waters website (www.waters.com).
Trademarks
ACQUITY™ is a trademark of Waters Corporation.
ACQUITY Arc™ is a trademark of Waters Corporation.
APGC™ is a trademark of Waters Corporation.
Arc™ is a trademark of Waters Corporation.
ASAP™ is a trademark of Waters Corporation.
ESCi™ is a trademark of Waters Corporation.
IntelliStart™ is a trademark of Waters Corporation.
MassLynx™ is a trademark of Waters Corporation.
Snoop® is a registered trademark of Swagelok Company.
Swagelok® is a registered trademark of Swagelok Company.
TargetLynx™ is a trademark of Waters Corporation.
THE SCIENCE OF WHAT'S POSSIBLE™ is a trademark of Waters Corporation.
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Tygon® is a registered trademark of Saint-Gobain Performance Plastics Corporation.
UNIFI™ is a trademark of Waters Corporation.
UniSpray™ is a trademark of Waters Corporation.
UPLC™ is a trademark of Waters Corporation.
UltraPerformance LC™ is a trademark of Waters Corporation.
UPC²™ is a trademark of Waters Corporation.
Viton® is a registered trademark of DuPont Performance Elastomers LLC.
Waters™ is a trademark of Waters Corporation.
Waters Quality Parts™ is a trademark of Waters Corporation.
waters_connect™ is a trademark of Waters Corporation.
Xevo™ is a trademark of Waters Corporation.
ZSpray™ is a trademark of Waters Corporation.
All other trademarks are property of their respective owners.
Customer comments
Waters’ Customer Experience and Knowledge Management organization invites you to report
any errors that you encounter in this document or to suggest ideas for otherwise improving it.
Help us better understand what you expect from our documentation so that we can continuously
improve its accuracy and usability.
We seriously consider every customer comment we receive. You can reach us at
Contacting Waters
Contact Waters with enhancement requests or technical questions regarding the use,
transportation, removal, or disposal of any Waters product. You can reach us through the
Internet, telephone, fax, or conventional mail.
Contact method Information
www.waters.com The Waters website includes contact
information for Waters locations worldwide.
iRequest Request technical support for your Waters
instruments and software. iRequest is a free
and secure Web service that allows you to
request support and service for Waters
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Contact method Information
instruments and software, or schedule a
planned service activity.
Note: In areas managed by authorized
distributors, iRequest may not be available.
Contact your local distributor for more
information.
Telephone and fax From the USA or Canada, phone
800-252-4752 or fax 508-872-1990.
For other locations worldwide, phone and fax
numbers appear in the Waters Local Offices
information.
Conventional mail Waters Corporation
Global Support Services
34 Maple Street
Milford, MA 01757
USA
Additional resources
Waters provides the following additional resources to ensure your continued success with our
products.
Knowledge base: Obtain quick answers to your troubleshooting questions. Access support
articles on Waters instrumentation, Informatics, and chemistry.
eLearning courses: Learn anytime, anywhere, and at your own pace with self-paced eLearning
courses.
Customer education: Waters Educational services team is the leading training organization
empowering scientists to maximize their skills in UPLC, HPLC, LC-MS, and data management.
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Application notes: View our online digital library of Application notes for advanced analytical
technologies including chromatography, mass spectrometry, columns and sample preparation,
and data management software, demonstrating impactful scientific and operational benefits.
How-to video library: View/download the latest product how-to videos.
Graphical parts locator: Identify and order parts using an interactive graphical navigator. Access
maintenance procedures and reference documents.
Waters online toolbox: A collection of wizards that help you pick the correct chemistry
consumables to meet your separation requirements, including vials, plates, filters, column
selectivity charts, and more
Intended use of the Xevo TQ-S cronos
Waters designed the Xevo TQ-S cronos for use as a research tool to accurately, reproducibly,
and robustly quantify target compounds present at the lowest possible levels in highly complex
sample matrices. The Xevo TQ-S cronos is not intended for use in diagnostic applications.
Calibrating
To calibrate LC systems, adopt acceptable calibration methods using at least five standards to
generate a standard curve. The concentration range for standards must include the entire range
of QC samples, typical specimens, and atypical specimens.
When calibrating mass spectrometers, consult the instrument’s online Help system for calibration
instructions.
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Quality control
Routinely run three QC samples that represent subnormal, normal, and above-normal levels of a
compound. If sample trays are the same or very similar, vary the location of the QC samples in
the trays. Ensure that QC sample results fall within an acceptable range, and evaluate precision
from day to day and run to run. Data collected when QC samples are out of range might not be
valid. Do not report these data until you are certain that the instrument performs satisfactorily.
EMC considerations
FCC radiation emissions notice
Changes or modifications not expressly approved by the party responsible for compliance could
void the user's authority to operate the equipment. This device complies with Part 15 of the FCC
Rules. Operation is subject to the following two conditions: (1) this device may not cause harmful
interference, and (2) this device must accept any interference received, including interference
that may cause undesired operation.
Canada spectrum management emissions notice
This class A digital product apparatus complies with Canadian ICES-001.
Cet appareil numérique de la classe A est conforme à la norme NMB-001.
ISM classification: ISM group 1 class A
This classification was assigned in accordance with CISPR 11 Industrial Scientific and Medical
(ISM) instruments requirements.
Group 1 products apply to intentionally generated and/or used conductively coupled radio-
frequency energy that is necessary for the internal functioning of the equipment.
Class A products are suitable for use in all establishments other than residential locations and
those directly connected to a low-voltage power supply network supplying a building for domestic
purposes.
There may be potential difficulties in ensuring electromagnetic compatibility in other environments
due to conducted and radiated disturbances.
This equipment complies with the emission and immunity requirements described in the relevant
parts of IEC/EN 61326: Electrical equipment for measurement, control, and laboratory use —
EMC requirements.
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EMC emissions
Do not use the equipment in close proximity to sources of strong electromagnetic radiation (for
example, unshielded intentional RF sources). The radiation can interfere with the equipment’s
proper operation.
EMC grounding requirements
Notice: To avoid difficulties in ensuring electromagnetic compatibility, if the
instrument's pump control cable is attached to the vacuum hose, ensure that the cable
is grounded to the mass spectrometer.
Legal manufacturer
Legal manufacturer:
Waters Corporation
34 Maple Street
Milford, MA 01757
USA
Safety considerations
Some reagents and samples used with Waters instruments and devices can pose chemical,
biological, or radiological hazards (or any combination thereof). You must know the potentially
hazardous effects of all substances you work with. Always follow Good Laboratory Practice
(GLP), and consult your organization’s standard operating procedures as well as your local
requirements for safety.
Applicable symbols
The following symbols can be present on the device, system, or packaging.
Symbol Definition
Manufacturer
Date of manufacture
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Symbol Definition
Confirms that a manufactured product complies
with all applicable European Community
directives
UK Conformity Assessed marking confirms that
a manufactured product is in conformity with
the applicable requirements for products sold
within Great Britain
Australia EMC compliant
Confirms that a manufactured product complies
with all applicable United States and Canadian
safety requirements
Confirms that a manufactured product complies
with all applicable United States and Canadian
safety requirements
Environmentally friendly use period (China
RoHS): indicates the number of years from the
date of manufacture until the product, or
components within the product, are likely to be
discarded or degrade into the environment
Consult instructions for use
Alternating current
Electrical and electronic equipment with this
symbol may contain hazardous substances and
should not be disposed of as general waste
For compliance with the Waste Electrical and
Electronic Equipment Directive (WEEE)
2012/19/EU, contact Waters Corporation for the
correct disposal and recycling instructions
For indoor use only
No pushing
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Symbol Definition
LC
Do not connect to an LC system
10kg
max
Indicates the maximum load you can place on
that item (for example, 10kg)
Serial number
REF
Part number, catalog number
Safety hazard symbol notice
The symbol indicates a potential hazard. Consult the documentation for important
information about the hazard and the appropriate measures to prevent and control the hazard.
Electrical power safety notice
Do not position the device so that it is difficult to disconnect the power cord.
Equipment misuse notice
If equipment is used in a manner not specified by its manufacturer, the protection provided by the
equipment may be impaired.
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Considerations specific to the device
Power cord replacement hazard
Warning: To avoid electric shock, observe these precautions:
• The power cord functions as the safety disconnect device. Position the equipment
so that you can reach the power cord easily.
• Use SVT-type power cords in the United States and HAR-type power cords, or
better, in Europe. For requirements elsewhere, contact your local Waters distributor.
• Do not replace power cords with inadequately rated power cords.
• Inspect the power cords for damage and replace them if necessary.
• Power-off and unplug a system module or stand-alone device before performing
any maintenance operation on it.
Solvent leakage hazard
The source exhaust system is designed to be robust and leak-tight. Waters recommends that you
perform a hazard analysis, assuming a maximum leak into the laboratory atmosphere of 10% LC
eluate.
Warning: To avoid exposure to toxic substances and biohazards from O-ring leaks in the source
exhaust system, observe these precautions:
• Replace the source O-rings at intervals not exceeding one year.
• Prevent chemical degradation of the source O-rings, which can withstand exposure only to
certain solvents, by determining whether any solvents you use are chemically compatible with
the composition of the O-rings.
Bottle placement prohibition
Warning: To avoid injury from electrical shock or fire, and damage to the equipment, follow
these guidelines:
• Do not expose the workstation or ancillary equipment to dripping or splashing liquids.
• Do not place objects filled with liquid, such as solvent bottles, on top of the workstation or
ancillary equipment.
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